mkt.schema.constants.LIST_PSEUDOKINASE_TRIAD_INTACT

mkt.schema.constants.LIST_PSEUDOKINASE_TRIAD_INTACT = ['BUB1B', 'PDIK1L', 'ROR1', 'ROR2', 'RYK', 'SBK3']

Curated pseudokinases that retain an intact VAIK-K / HRD-D / DFG-D triad and are therefore NOT caught by the catalytic-residue heuristic (false negatives); they are catalytically dead for other reasons (degraded regulatory spine, glycine-rich loop, or nucleotide binding). is_pseudokinase() force-returns True for these.

Citations:

• BUB1B (BUBR1) – a bona fide pseudokinase despite an intact catalytic triad: Suijkerbuijk et al., Dev Cell 2012; Murphy et al., Biochem J 2014.

• ROR1, ROR2, RYK – Wnt-receptor pseudokinases that retain catalytic residues but lack activity: Boudeau et al., Trends Cell Biol 2006; Reiterer et al., Trends Cell Biol 2014; Mendrola et al., Biochem Soc Trans 2013.

• PDIK1L, SBK3 – annotated pseudokinases with intact triads; classified pseudo on nucleotide-binding / catalytic grounds (Murphy et al., Biochem J 2014). Lower confidence than the above; revisit if a more authoritative list is adopted.

Type:

list[str]