mkt.schema.constants.LIST_PSEUDOKINASE_HEURISTIC_FALSE_POSITIVE

mkt.schema.constants.LIST_PSEUDOKINASE_HEURISTIC_FALSE_POSITIVE = ['CAMKK1', 'STYK1']

Kinases the catalytic-residue heuristic flags as pseudokinases but that are (debatably) catalytically active – false positives held out for review. is_pseudokinase() force-returns False for these. Status is genuinely contested in the literature.

Citations / rationale:

• STYK1 (NOK, “Novel Oncogene with Kinase domain”) – fails only DFG-D (xDFG:81 = G); reported as an active oncogenic kinase by some and as catalytically deficient by others, i.e. unresolved: Reiterer et al., Trends Cell Biol 2014; Kung & Jura, Structure 2016.

• CAMKK1 – a well-established active Ca2+/calmodulin-dependent kinase kinase (Haribabu et al., EMBO J 1995) whose KLIFS pocket is anomalously degraded here (III:17=M, c.l:70=R, xDFG:81=A), most consistent with a pocket alignment/annotation artifact rather than true loss of catalysis.

NOTE (WNK4): WNK4 also trips the heuristic (no beta3 or beta2 lysine; III:17=C, II:13=R) and is NOT rescued by the beta2-lysine alternative, unlike WNK1/2/3. WNK4 is the most divergent, weakly/debatably active WNK – left flagged pending review rather than added here.

Type:

list[str]