mkt.databases.conservation.LIST_RESIDUE_DOT_KINASES

mkt.databases.conservation.LIST_RESIDUE_DOT_KINASES = ['EGFR', 'BTK', 'FGFR1', 'FGFR2', 'FGFR3', 'FGFR4']

Clinically relevant kinases of interest whose covalent-targetable residues are called out on the static dot plot. Columns are not hardcoded: every KLIFS column where at least INT_RESIDUE_DOT_MIN_SHARED of these kinases carry the plotted residue is boxed (_annotation_callouts()), with kinases sharing a homologous column grouped in one box. For cysteine this captures all of these kinases’ pocket cysteines – FGFR1-4 at g.l:7 and VI:66, EGFR C797 / BTK C481 at linker:52, plus the singletons EGFR C775 (b.l:36), FGFR4 C552 (hinge:47), and BTK C527 (VII:76) – and tracks the current KLIFS mapping.

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list[str]