mkt.databases.protvar.ProtvarVariant

class mkt.databases.protvar.ProtvarVariant(mt: str | None, scores: dict = <factory>)[source]

Bases: object

Scores for a single variant (one mutant residue) at a position.

Built by ProtvarScoreQuery; holds the raw per-database score dict for this variant and exposes scalar accessors. Conservation, which is residue- rather than variant-level, is shared across all variants at the position.

__init__(*args: Any, **kwargs: Any) → None

Methods

`__eq__`(other)	Return self==value.
`get_classification`(database)	Return the categorical classification for a database, or None.
`get_popeve`()	Return the standalone popEVE payload for this variant, or None.
`get_score`(database)	Return the numeric score for a database, or None if not present.

Attributes

`__dataclass_fields__`
`__dataclass_params__`
`__match_args__`
`__pydantic_config__`
`mt`	Mutant residue (1-letter code) this variant represents; None if unknown.
`scores`	Mapping of ScoreDatabase to its raw score dict for this variant.

get_classification(database: ScoreDatabase | str)[source]

Return the categorical classification for a database, or None.

Parameters:: database (ScoreDatabase | str) – Database to retrieve, as a ScoreDatabase member or its value (e.g. “AM”).
Returns:: The classification (“eveClass” for EVE, “amClass” for AlphaMissense); None for databases without one (Conservation, ESM1b, popEVE) or when the database is absent for this variant.
Return type:: str | None

get_popeve() → dict | None[source]

Return the standalone popEVE payload for this variant, or None.

Returns:: The full popEVE score dict (multiple keys, retained verbatim), or None if popEVE was not returned for this variant.
Return type:: dict | None

get_score(database: ScoreDatabase | str)[source]

Return the numeric score for a database, or None if not present.

Parameters:: database (ScoreDatabase | str) – Database to retrieve, as a ScoreDatabase member or its value (e.g. “AM”).
Returns:: The score (“score” for Conservation/EVE/ESM1b, “amPathogenicity” for AlphaMissense); None for popEVE (use get_popeve()) or when the database is absent for this variant.
Return type:: float | None

mt: str | None: Mutant residue (1-letter code) this variant represents; None if unknown.

scores: dict: Mapping of ScoreDatabase to its raw score dict for this variant.